23 December, 2025
experts-address-barriers-to-pcsk9-therapies-in-ascvd-treatment

Recent discussions among healthcare experts have highlighted significant barriers that restrict the use of PCSK9-targeting therapies in the management of Atherosclerotic Cardiovascular Disease (ASCVD). Despite robust evidence demonstrating their efficacy and safety, these therapies remain underutilized due to various systemic issues.

Cost remains a formidable obstacle. Many patients eligible for PCSK9 therapies encounter high out-of-pocket expenses, compounded by restrictive insurance policies. According to the panelists, the lengthy prior authorization processes often lead to treatment delays or outright denials. This situation creates gaps in treatment, leaving both patients and clinicians frustrated with the current healthcare system.

Impact on Healthcare Teams

The administrative burden on healthcare teams is another critical concern. Panelists noted that clinicians frequently spend an excessive amount of time dealing with paperwork and appeals related to therapy access. This not only detracts from patient care but also contributes to clinician burnout, as the focus shifts from direct patient interaction to navigating complex approval processes.

Even when patients manage to secure access to these therapies, a lack of awareness among some clinicians regarding the most effective use of PCSK9 treatments can impede timely initiation of therapy. The panel emphasized that improving education among healthcare providers is essential.

They advocate for simplified approval pathways and enhanced affordability of these therapies. By addressing these issues, the healthcare community could significantly improve access to effective LDL-C lowering treatments, which are proven to reduce the risk of recurrent ASCVD events.

The experts concluded that overcoming these administrative and systemic hurdles is vital. Ensuring that more patients can benefit from proven therapies will ultimately lead to better outcomes in ASCVD care, reducing the overall burden of cardiovascular disease on communities worldwide.