Kelley Mack, a promising actress known for her roles in popular television series, passed away at the age of 33 in August 2025 after a courageous struggle with a rare form of brain cancer known as diffuse midline glioma. Mack had recently gained recognition for her performance in The Walking Dead and was actively promoting upcoming projects during the final months of her life.
Born in Ohio, Mack was not only an actress but also a producer and voiceover artist. Her notable performances included roles in Chicago Med and Broadcast Signal Intrusion. Fans admired her versatility, and her career seemed to be on the rise as she navigated various creative endeavors.
Understanding Kelley Mack’s Diagnosis
In January 2025, Mack revealed her diagnosis of diffuse midline glioma, a type of astrocytoma, which is a malignant tumor that forms from glial cells in the brain or spinal cord. The National Cancer Institute defines astrocytomas as tumors that arise from astrocytes, a type of glial cell that supports and protects neurons.
Mack shared her journey on social media, detailing the symptoms that led to her diagnosis. In an Instagram post, she described experiencing persistent lower back pain, neuropathic itching, and shooting pains that ultimately required her to seek emergency medical attention. After undergoing an MRI, doctors discovered an abnormal mass in her spinal cord.
Following a biopsy, Mack faced significant physical challenges, losing mobility in her legs and requiring a walker and wheelchair. Despite these hardships, she maintained a positive outlook, expressing her determination to continue her acting career, albeit with some adjustments during her treatment in Cincinnati, Ohio.
The Impact of Gliomas and Mack’s Legacy
A glioma is categorized as a malignant tumor that develops when glial cells multiply uncontrollably. According to the Cleveland Clinic, gliomas are classified into three main types: astrocytomas, ependymomas, and oligodendrogliomas. Mack’s specific diagnosis of diffuse midline glioma falls under the astrocytoma category, which includes various forms such as glioblastomas and diffuse intrinsic pontine gliomas (DIPGs).
Mack’s battle with cancer resonated with many, inspiring her fans and fellow artists alike. She communicated her belief that this challenging chapter would eventually be a small part of her life story. As she continued to work on her upcoming projects, her dedication to her craft remained evident until her passing.
While the precise cause of Kelley Mack’s death has not been disclosed, her impact on the entertainment industry and the hearts of her audience will not be forgotten. Her story serves as a reminder of the resilience of the human spirit in the face of adversity.
