9 November, 2025
nfl-week-10-predictions-key-matchups-and-odds-for-sunday

As the NFL enters Week 10 of the 2025 season, teams are intensifying their efforts to secure playoff positions. With the season now in double digits, some squads are looking to recover from lackluster first halves, while others begin to strategize for the 2026 season. This weekend’s schedule features an international game and the return of morning football, while four teams—the Cincinnati Bengals, Dallas Cowboys, Kansas City Chiefs, and Tennessee Titans—will enjoy their bye week.

Among the notable matchups, the Miami Dolphins will face the Buffalo Bills for the second time this season. The Bills, boasting a record of 6-2, will enter the game as significant favorites, leaving the Dolphins, who currently stand at 2-7, with high stakes and little expectation for success. Historically, Buffalo has dominated this rivalry, but the Dolphins hope to defy the odds and pull off an upset.

Key Matchups and Odds

Sunday’s schedule is packed with compelling games, starting early in the day. All odds are provided by FanDuel Sportsbook:

– **9:30 a.m. Eastern**
Atlanta Falcons vs. (-6.5) Indianapolis Colts – Berlin, Germany

– **1 p.m. Eastern**
New Orleans Saints at (-5.5) Carolina Panthers
New York Giants at (-4.5) Chicago Bears
Jacksonville Jaguars (-1.5) at Houston Texans
Buffalo Bills (-9.5) at Miami Dolphins
Baltimore Ravens (-4.5) at Minnesota Vikings
Cleveland Browns (-2.5) at New York Jets
New England Patriots at (-2.5) Tampa Bay Buccaneers

– **4:05 p.m. Eastern**
Arizona Cardinals at (-7) Seattle Seahawks

– **4:25 p.m. Eastern**
Los Angeles Rams (-5.5) at San Francisco 49ers
Detroit Lions (-7.5) at Washington Commanders

– **8:20 p.m. Eastern**
Pittsburgh Steelers at (-2.5) Los Angeles Chargers

As the games unfold, our contributors will offer predictions for each matchup, tracking their straight-up winner picks throughout the season. For those interested, there is an opportunity to participate in the predictions as well. Simply sign up using the link provided in the widget at the end of this article.

Contributor Standings

Following the conclusion of Week 9, our contributors have shown impressive insight into the games. Here are the current standings:

Sumeet Jena: 91-44-1
James McKinney: 88-47-1
Kevin Nogle: 87-48-1
Marek Brave: 86-49-1

As excitement builds for this weekend’s matchups, fans will be keeping a close eye on both the outcomes and the performance of their favorite teams. Whether it’s a battle for playoff positioning or a quest for pride, Week 10 promises to deliver thrilling football action.